Endothelin antiserum decreases volume-stimulated and basal plasma concentration of atrial natriuretic peptide.
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چکیده
منابع مشابه
Endothelin antiserum decreases volume-stimulated and basal plasma concentration of atrial natriuretic peptide.
BACKGROUND Endothelin-1 (ET-1) is the most powerful factor known to release atrial natriuretic peptide (ANP) in vivo and in cultured cardiac myocytes or preparations of atrium. We tested the role of endogenous ET-1 in the regulation of ANP release by passive immunization in anesthetized rats. METHODS AND RESULTS Intravenous injection of antiserum against ET-1 was shown to decrease basal and v...
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In this study we examined the mechanism whereby atrial natriuretic peptide secretion is increased when the frequency of contraction is raised from 2 to 5 Hz. We tested the hypothesis that calcium plays a significant role in the frequency-stimulated response. Using superfused rat left atria, we found that lowering the superfusate calcium concentration from 1.8 to 0.2 mmol/L abolished the frequen...
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متن کاملAtrial natriuretic peptide: an essential physiological regulator of transvascular fluid, protein transport, and plasma volume.
Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3 mechanisms: increased renal excretion of salt and water, vasodilation, and increased vascular permeability. Authors of a study in this issue of the JCI performed a knockout of the receptor for ANP in vascular endothelia in order to distinguish the effects of ANP-dependent increases in vascular permeability from ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1993
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.88.3.1172